Wash and chop the broccoli florets finely, then set aside.
In a large mixing bowl, combine chopped broccoli, cheddar cheese, breadcrumbs, Parmesan cheese, and egg. Add garlic powder, onion powder, salt, and black pepper. Mix well.
Form the mixture into bite-sized balls, about 1 inch in diameter, and place them on a plate.
Preheat the air fryer to 375°F. Spray the basket with cooking spray and place the bites in a single layer. Air fry for 10-12 minutes, shaking the basket halfway through.
Remove the bites from the air fryer and let them cool for a few minutes before serving.